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daily : 2016-12-08 & on time : 23:31
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New drug combo shows promise curbing tough-to-treat breast cancer
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THURSDAY, Dec. 8, 2016 -- In women with a certain form of tough-to-treat breast cancer, treatment with a combination of two drugs appeared to keep the cancer at bay longer -- from about five months to 10, a new study says.The cancer is known as "advanced hormone receptor positive, HER 2 negative" breast cancer.Women with these tumors are often given drugs called aromatase inhibitors, which work by reducing estrogen in the body and slowing the growth of the cancer.However, patients commonly develop resistance to aromatase inhibitor drugs, and they stop working.
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Scientists identify biomarkers to predict patient's response to breast cancer treatment
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Why do some breast cancers respond to treatment while others resist it?A study led by researchers at the University of North Carolina Lineberger Comprehensive Cancer Center may provide insight into this important question.The researchers report at the San Antonio Breast Cancer Symposium that they have identified biomarkers they believe can be used as part of a larger model to predict how patients with HER2-positive operative breast cancer will respond to the targeted treatment trastuzumab, commercially known as Herceptin, and chemotherapy."We're trying to find biomarkers for resistance to trastuzumab treatment and chemotherapy," said the study's first author Maki Tanioka, MD, PhD, a postdoctoral research associate at UNC Lineberger.
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New drug combination shows early promise for some breast cancer patients
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A combination of two drugs could help some breast cancer patients with advanced cancer live longer, according to a small clinical trial.The treatment duo delayed the time it took for the disease to get worse in women with advanced breast cancer compared to those given just one of the drugs, according to the results presented at the San Antonio Breast Cancer Symposium in the US this week."We need new treatments for women with this form of breast cancer" – Professor Arnie Purushotham, Cancer Research UKDr Noah Kornblum from Albert Einstein College of Medicine in the US and one of the researchers behind the study, urged caution "until larger studies confirm our results".But he said the combination could offer an alternative treatment approach for some women with breast cancer in the future.
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