Experts reveal breast cancer breakthrough: Spread could be stopped with diabetes drug : express

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Experts reveal breast cancer breakthrough: Spread could be stopped with diabetes drug

Experts reveal breast cancer breakthrough: Spread could be stopped with diabetes drug

GETTY Hardly any tumours were found when the drug was usedResearchers in the US believe the key to fighting the development of a protein associated with the disease could be pioglitazone, a drug typically used to treat type two diabetes by reducing insulin resistance.They found that reducing the level of the protein NAF-1 and the activity of the iron-sulfur clusters it transports, may be the answer to halting tumour growth.The team, including scientists from Rice University, Texas, and scientists from Israel, the University of California, San Diego (UCSD) and the University of North Texas, discovered that a single mutation can stop growth.Just one mutation to NAF-1 almost completely blocked the ability of cancer cells to multiply, a result they said supports the idea that lowering NAF-1 expression can help stop tumours.


in like manner sciencecodex

New tools join breast cancer fight

New tools join breast cancer fight

Posted By News On September 12, 2016 - 11:35pmHOUSTON - (Sept. 12, 2016) - An international team including Rice University researchers has discovered a way to fight the overexpression of a protein associated with the proliferation of breast cancer.Dialing down the level of the protein NAF-1 and the activity of the iron-sulfur clusters it transports may be key to halting tumor growth, they reported.In a study this week in the Proceedings of the National Academy of Sciences, the researchers suggest a drug that is typically used to treat type 2 diabetes, pioglitazone, has proven effective at controlling NAF-1 levels.They also discovered that a single mutation to NAF-1 almost completely blocked the ability of cancer cells to proliferate, a result they said supports the idea that lowering NAF-1 expression can help stop tumors.


as well eurekalert

Therapeutic inhibition of RANK pathway reduces breast cancer recurrence

Therapeutic inhibition of RANK pathway reduces breast cancer recurrence

Researchers at the Institute of Biomedical Research of Bellvitge (IDIBELL), led by Dr. Eva Gonzalez-Suarez, have shown that pharmacological and genetic inhibition of signaling pathway RANK / RANKL leads to a significant reduction in recurrences and metastases in breast cancer in a mouse animal model.Their findings, published in Cancer Research, suggest that RANK inhibitors currently used in patients with osteoporosis and bone metastases may have potential for treating breast cancer.Cancer stem cells (CSC) express high levels of RANK protein."In fact, mortality in breast cancer is mainly due to survivor CSC after treatments, which are responsible for tumor recurrence and metastasis" explains Dr. González-Suárez.