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Landmark clinical trial to test third investigational drug for Alzheimer's disease
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An international team led by Washington University School of Medicine in St. Louis has selected a third investigational drug to be tested in a worldwide clinical trial - already underway - aimed at finding treatments to prevent Alzheimer's disease.The third drug is being developed by Janssen Research & Development, LLC, in New Jersey.It is designed to lower production of amyloid beta, a protein that clumps together into plaques and damages neurons in the brain, leading to memory loss, cognitive problems and confusion.The drug is designed to block the enzyme beta secretase -- which produces amyloid beta -- with a goal of reducing the amount of amyloid beta available to clump and cause neurodegeneration.
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Acadia says Alzheimer's disease psychosis drug clears study
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Acadia says Alzheimer's disease psychosis drug clears studyDec 20 (Reuters) - Acadia Pharmaceuticals Inc said on Tuesday its drug to treat psychosis in patients suffering from Alzheimer's disease met its main goal in a mid-stage study.The company said the drug, pimavanserin, showed a statistically significant reduction in psychosis with a 3.76 point improvement at week 6, compared with 1.93 for placebo.Acadia said a total of 181 patients were enrolled in the study in the UK and randomized on a one-to-one basis to receive either 34 mg of pimavanserin or placebo once everyday.The drug has been approved by the US Food and addiction Administration to treat hallucinations and delusions associated with Parkinson's disease psychosis, the company said.
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New biomarker predicts Alzheimer's disease and link to diabetes
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Diagram of the brain of a person with Alzheimer's Disease.Credit: Wikipedia/public domain.An enzyme found in the fluid around the brain and spine is giving researchers a snapshot of what happens inside the minds of Alzheimer's patients and how that relates to cognitive decline.Iowa State University researchers say higher levels of the enzyme, autotaxin, significantly predict memory impairment and Type 2 diabetes.
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