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daily : 2016-12-29 & on time : 20:55
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Immune therapy success against brain cancer stirs excitement
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This March 2016 photo provided by the City of Hope hospital shows patient Richard Grady in Duarte, Calif.Suffering from a deadly brain cancer that had spread to his spine, a novel therapy which helped his immune system attack his disease shrank his tumors.An experimental immune therapy temporarily wiped out tumors in the brain and spinal cord of a patient with recurrent glioblastoma, one of the most lethal of all cancers.Researchers at the City of Hope in Duarte, Calif., genetically engineered 50-year-old Richard Grady's own T cells to attack his tumors, which shrank and disappeared over 7.5 months.
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Revolutionary treatment at City of Hope helps man fight deadly brain cancer
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A man with deadly brain cancer that had spread to his spine saw his tumors shrink and, for a time, completely vanish after a novel treatment to help his immune system attack his disease - another first in this promising field.The type of immunotherapy that 50-year-old Richard Grady received already has helped some people with blood cancers such as leukemia.But the way he was given it is new, and may allow its use not just for brain tumors but also other cancers that can spread, such as breast and lung.Grady was the first person to get the treatment dripped through a tube into a space in the brain where spinal fluid is made, sending it down the path the cancer traveled to his spine.He had "a remarkable response" that opens the door to wider testing, said Dr. Behnam Badie, neurosurgery chief at City of Hope, a cancer center in Duarte, California, where Grady was treated.The case is reported in this week's New England Journal of Medicine.Each year in the United States, about 20,000 people are diagnosed with a type of brain tumor called glioblastoma.Grady, who lives in Seattle, had the usual surgery, radiation and chemotherapy, but the cancer came back.He enrolled in a clinical trial at City of Hope and had some of his own blood cells, called T cells, removed and genetically modified in the lab to turn them into specialized soldiers to seek and destroy cancer.The treatment, called CAR-T cell therapy, has been used for blood cancers, but its value for solid tumors is unknown.City of Hope has been testing injecting the cells directly into the brain.First, Grady had more surgery to remove three of his largest tumors.Then he got six weekly infusions of the cells through a tube into his brain, where the biggest one had been.No cancer recurred there, but the remaining tumors continued to grow, new ones appeared, and cancer spread to his spine.Doctors decided on a bold step: placing a second tube in his brain, into a cavity where spinal fluid is made, and putting the cells there.
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CAR-T therapy makes early inroads in treating brain cancer
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Glioblastoma is one of the deadliest cancers — an illness that responds to few treatment options, and often poorly.But a single case study that uses an experimental immunotherapy to treat these brain tumors might give oncologists a new way to approach the disease.The therapy, called CAR-T, is controversial and has faced hurdles in clinical trials.It has shown great promise in treating blood cancers like leukemia and lymphoma — but has proven challenging in treating other forms of the disease, including solid tumors.
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