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Friday, December 30, 2016

Nanodiscs Deliver Personalized Cancer Therapy to Immune System stat : genengnews

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MPI and OV Ink 3-Year Deal for Personalized Cancer Therapy Gene Signature Platform


MPI and OV Ink 3-Year Deal for Personalized Cancer Therapy Gene Signature Platform
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Medical Prognosis Institute (MPI) and its spin-out Oncology Venture Sweden (OV) have inked a series of deals with respect to use of MPI's addiction Response Prediction (DRP™) technology for developing tumor-derived genetic signatures for personalized cancer therapy.Under terms of the deal, MPI has granted OV exclusive, 3-year wordwide rights to the DRP platform for use in drug development and in the clinical field.The rights extend to use of the technology by OV's existing U.S. spin-out 2X Oncology for three anticancer products, and by a new OV special purpose vehicle (SPV), OV-SPV2 project tyrosine kinase inhibitor, for one high-risk product.MPI and OV also reported that $4 million in seed funding has been secured for the two SPVs.
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Nanodiscs Deliver Personalized Cancer Therapy to Immune System


Nanodiscs Deliver Personalized Cancer Therapy to Immune System
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Researchers at the University of Michigan have had initial success in mice using nanodiscs to deliver a customized therapeutic vaccine for the treatment of colon and melanoma cancer tumors."We are basically educating the immune system with these nanodiscs so that immune cells can attack cancer cells in a personalized manner," said James Moon, the John Gideon Searle assistant professor of pharmaceutical sciences and biomedical engineering.Personalized immunotherapy is a fast-growing field of research in the fight against cancer.The therapeutic cancer vaccine employs nanodiscs loaded with tumor neoantigens, which are unique mutations found in tumor cells.
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Researchers Successfully Treat Mice with Personalized Cancer Vaccines


Researchers Successfully Treat Mice with Personalized Cancer Vaccines
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A team of researchers from the University of Michigan developed personalized therapeutic vaccines for treating certain kinds of cancer.The team used nanodiscs to deliver the treatments and the method was successful in treating live mice.The findings are in a paper that was just published in the journal Nature Materials.Most modern cancer treatments, including chemotherapy, are generalized and not based on the patient's specific needs.
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