Gene that may strongly influence obesity uncovered -- ScienceDaily stat : sciencedaily

Sokolowski says it's particularly interesting that one gene should have multiple roles in feeding and obesity in the body, a characteristic known as pleiotropy. A University of Toronto (U of T) study on fruit flies has uncovered a gene that could play a key role in obesity in humans. "Lots of genes have multiple roles, but the idea here is that this gene may be involved in the coordination of roles in traits important for feeding and obesity." The next question would be how exactly it plays multiple roles. In nature, fruit flies called "rovers" with high amounts of the gene tend to move a lot, eat very little and stay lean, while flies with low amounts of for called "sitters" are the opposite.




Epigenetic changes affect the formation of new muscle cells and may be a contributing factor to reduced muscle mass and impaired metabolism found in obesity. The study, led by Cajsa Davegardh, a doctoral student at Lund University, compared DNA methylation in muscle stem cells in obese and non-obese people. Results showed the pro-inflammatory gene IL-32 played a vital role in gene maturation and insulin sensitivity in fully mature muscle cells. "We believe that in obese individuals the muscle stem cells have been reprogrammed, and that this may partly explain why muscle cells in obese people have decreased insulin sensitivity and lower metabolism after they have matured," Davegardh said. Impairment of insulin sensitivity is common in obesity and type 2 diabetes.


​Mediterranean diet may decrease pain associated with obesity Those who eat more fish, plant proteins less likely to suffer, study findsCOLUMBUS, Ohio – Eating a Mediterranean diet could decrease the chances an overweight person will experience regular pain, new research suggests. And they tested the model using three different measures of weight – body mass index, waist circumference and body fat percentage. Eating more fish and plant-based proteins such as nuts and beans was linked with less pain, regardless of body weight. The pain evaluation provides an indicator of pain experienced during the previous month, but does not account for chronic pain of a longer duration. Emery said his next step is to examine body fat and pain using biomarkers associated with inflammation.



collected by :Lucy William

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