Triple-therapy patch may treat, prevent recurrence of colon cancer : upi

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Triple-therapy patch may treat, prevent recurrence of colon cancer

Triple-therapy patch may treat, prevent recurrence of colon cancer

BOSTON, July 29 (UPI) -- A patch delivering one, two or three types of colon cancer treatment could make surgery for the disease unnecessary, according to researchers who developed it.Gene therapy, chemotherapy, thermal ablation, or a combination of the three, can be delivered by a hydrogel patch, a method shown to shrink tumors in mice, preventing recurrence and extending the rodents' survival, according to a study published in the journal Nature Materials.AdvertisementAfter a colon cancer diagnosis, surgery is generally part of the treatment plan, but researchers who developed the patch say it could change the way the disease is treated -- potentially eliminating the need for surgically removing tumors."Our preclinical results are remarkable," Dr. Natalie Artzi, a researchers at Brigham and Women's Hospital, said in a press release.


in addition denverpost

Collaboration — and fruit flies — suggest potential strategy for colon cancer in CU study – The Denver Post

Collaboration — and fruit flies — suggest potential strategy for colon cancer in CU study – The Denver Post

A chance encounter five years ago at a summer symposium, a shared interest in genetics — and some fruit flies — pointed University of Colorado researchers toward a laboratory collaboration that yielded potentially significant advances in dealing with colorectal cancer.The findings, published in the journal Cell Reports, suggest a possible new strategy for attacking tumors by targeting specific enzymes that help a protein, called HIF1A, enable tumor cells to adapt to low levels of oxygen.While HIF1A can't be shut down by drugs, the two enzymes, called CDK8 and TIP60, can be medicated to inhibit tumor growth.If results continue to hold true in further studies, they could have implications for the treatment not only of colon cancer, but other varieties as well.


coupled with nanowerk

Triple-therapy patch delivers local treatment, prevents recurrence in colon cancer model

Triple-therapy patch delivers local treatment, prevents recurrence in colon cancer model

Triple-therapy patch delivers local treatment, prevents recurrence in colon cancer model (Nanowerk News) Investigators at Brigham and Women's Hospital have developed a hydrogel patch that can adhere to tumors in a preclinical model of colon cancer, delivering a local, combination treatment as the elastic gel breaks down over time.The new technique may allow clinicians to one day use diagnostic colonoscopy equipment to immediately deliver treatment without the need for open surgery at a later date.The team's findings are published in the July 25 issue of Nature Materials ("Local triple-combination therapy results in tumour regression and prevents recurrence in a colon cancer model").The researchers were able to deliver three therapeutic strategies in their mouse model of colon cancer: gene therapy, chemotherapy or thermal ablation or a combination of all three.