as declared in fiercebiotech
BET inhibitor tamps down PD-L1 activity in ovarian cancer cells
BET inhibitor tamps down PD-L1 activity in ovarian cancer cells
Wistar Institute scientists have found a class of drugs that effectively dampened PD-L1 activity in ovarian cancer, even though it does not directly target PD-L1.Called bromodomain and extraterminal domain (BET) inhibitors, multiple candidates are in clinical trials for other cancers.The interaction between the PD-1 protein and its ligand, PD-L1, blocks T cells from fighting tumor growth.But antibody-based drugs that disrupt this interaction can cause immune-related side effects, the scientists said in a statement.
not to mention news-medical
BET inhibitors could be powerful new therapeutic strategy for ovarian cancer
BET inhibitors could be powerful new therapeutic strategy for ovarian cancer
Few effective treatments have been approved to treat ovarian cancer, the deadliest of all cancers affecting the female reproductive system.Now, new research from The Wistar Institute demonstrates how a drug already in clinical trials could be used to boost anti-tumor immunity and cause T-cells to target the cancer directly while minimizing side effects.The results were published in the journal Cell Reports.There has been considerable interest in the programmed cell death-1 (PD-1) protein and its ligand (PD-L1) because the interaction between the two inhibits important T-cell activity aimed at stopping tumor growth.
not to mention thestate
Butterfly release to raise funds for ovarian cancer awareness
Butterfly release to raise funds for ovarian cancer awareness
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