Scientists discover 'switch' for aggressive breast cancer cells : upi

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Scientists discover 'switch' for aggressive breast cancer cells

Scientists discover 'switch' for aggressive breast cancer cells

SINGAPORE, Nov. 1 (UPI) -- A research team from the National University of Singapore has identified a trigger that makes breast cancer cells more aggressive.In a study published in the journal Antioxidants & Redox Signaling, scientists isolated the enzyme manganese superoxide dismutase, or MnSOD, as the culprit behind invasive behavior.The study's authors say the findings open opportunities for the potential development of new breast cancer treatments.MnSOD was found to have a central role in breast cancer cell aggression, including the formation of secondary tumors.


moreover from sciencedaily

Scientists discover the 'switch' that makes breast cancer cells aggressive -- ScienceDaily

Scientists discover the 'switch' that makes breast cancer cells aggressive -- ScienceDaily

A team of scientists from the National University of Singapore (NUS) has established novel insights into the relationship between breast cancer tumour intracellular redox environment and the cancer cells' ability to become invasive.The study by Dr Alan Prem Kumar from the Cancer Science Institute of Singapore (CSI Singapore) at NUS and NUS Yong Loo Lin School of Medicine, together with Professor Shazib Pervaiz and Associate Professor Marie-Veronique Clement from NUS Yong Loo Lin School of Medicine, found that high levels of Manganese Superoxide Dismutase (MnSOD), a key enzyme involved in regulating the cellular redox milieu, has a role to play in causing breast cancer cells to turn aggressive, especially in triple negative breast cancer subtype tumours.These aggressive cells are able to invade other sites in the body, resulting in secondary tumours."Our group's work over the years has highlighted the critical role of cancer cells' oxidative metabolism in drug resistance and cell survival.


in like manner news-medical

Genetic susceptibility could help identify breast cancer patients at risk of developing VTE

Genetic susceptibility could help identify breast cancer patients at risk of developing VTE

Bottom Line: Genetic testing could help identify breast cancer patients with high risk of experiencing venous thromboembolism (VTE), a serious and potentially fatal complication that can occur during cancer treatment.Journal in Which the Study was Published: Clinical Cancer Research, a journal of the American Association for Cancer Research.Author: Judith S. Brand, PhD, a postdoctoral researcher in the Department of Medical Epidemiology and Biostatistics at Karolinska Institutet in Stockholm, Sweden.Background: "The risk for venous thromboembolism (the formation of blood clots in a vein) is increased in cancer patients, particularly in those receiving chemotherapy," Brand said.


by the same token on dailytarheel

Local middle school raises money for pink jerseys and breast cancer awareness

Local middle school raises money for pink jerseys and breast cancer awareness

Local middle school raises money for pink jerseys and breast cancer awarenessEllie Little | Published 7 hours agoMcDougle Middle School's football team, with help from Team Moms Denise Page (left) and Shana Harper, raised money for pink uniforms and a donation to the Susan G. Komen Foundation, in support of Breast Cancer Awareness.Photo by Nicholas Bafia / The Daily Tar HeelThe team raised over $2,800 for the jerseys and donation.Nearly $2,200 of this money went toward pink jerseys for the boys to wear for the whole month of October.Denise Page, one of the team moms, said $626 of that money was presented in a jumbo check to the Susan G. Komen breast cancer organization at the team's last home game on Oct. 26. https://www.facebook.com/denise.page.75?fref=tsCoach Chris Clark said he was inspired to raise the money after people in his family and community were affected by breast cancer.