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daily : 2016-12-18 & on time : 8:36
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Certain high blood pressure drugs block cancer invasion -- ScienceDaily
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Researchers at the University of Turku, Finland have identified a new way of blocking the spread of cancer.Calcium channel blockers, which are used to lower blood pressure, block breast and pancreatic cancer invasion by inhibiting cellular structures.By screening already approved drugs, the team led by Postdoctoral Researcher Guillaume Jacquemet and Academy Professor Johanna Ivaska has discovered that calcium channel blockers can efficiently stop cancer cell invasion in vitro.Calcium channel blockers are currently used to treat hypertension, also known as high blood pressure, but their potential use in blocking cancer cell metastases has not been previously reported.
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Good news: Blood pressure lowering drugs may block cancer invasion
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Drugs used to lower blood pressure can potentially block breast and pancreatic cancer invasion by inhibiting their cellular structures, say researchers.The study discovered that calcium channel blockers -- currently used to treat hypertension -- can efficiently stop cancer cells move and invade surrounding tissue.Identification of anti-hypertension drugs as potential therapeutics against breast and pancreatic cancer metastasis was a big surprise, said reseachers.Read moreThe targets of these drugs were not known to be present in cancer cells and therefore no one had considered the possibility that these drugs might be effective against aggressive cancer types, said Johanna Ivaska at the University of Turku in Finland.
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Certain high BP drugs cut spread of cancer in body
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A team of researchers has found that drugs used to treat high blood pressure can block the spread of cancer The findings were published in journal of Nature Communications.Calcium channel blockers are currently used to treat hypertension, also known as high blood pressure, but their potential use in blocking cancer cell metastases has not been previously reported.By screening already approved drugs, the team led by Postdoctoral Researcher Guillaume Jacquemet and Academy Professor Johanna Ivaska from University of Turku in Finland discovered that calcium channel blockers can efficiently stop cancer cell invasion in vitro.According to researchers, identification of anti-hypertension drugs as potential therapeutics against breast and pancreatic cancer metastasis was a big surprise."The targets of these drugs were not know to be present in cancer cells and therefore no one had considered the possibility that these drugs might be effective against aggressive cancer types," said lead study author Johanna IvaskaThey focused their efforts on understanding how cancer cells move and invade surrounding tissue.The team has identified that aggressively spreading cancer cells express a protein called Myosin-10 which drives cancer cell motility.Myosin-10 expressing cancers have a large number of structures called filopodia .They are sticky finger-like structures the cancer cells extend to sense their environment and to navigate -- imagine a walking blind spider, explains Dr Jacquemet.They found that calcium channel blockers target specifically these sticky fingers rendering them inactive, thus efficiently blocking cancer cell movement.This suggested that they might be effective drugs against cancer metastasis.However, at this stage much more work is required to assess if these drugs would be efficient against cancer progression.
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