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Gum Disease Linked to Autoimmunity in Rheumatoid Arthritis
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MedicalResearch.com Interview with:Maximilian F. Konig, MDDivision of Rheumatology,Johns Hopkins University School of MedicineCurrent affiliation:Department of MedicineMassachusetts General HospitalHarvard Medical SchoolMedicalResearch.com: What is the background for this study?Response:The idea that rheumatoid arthritis (RA), an autoimmune disease that leads to chronic joint inflammation and destruction, may be initiated by a bacterial infection is not novel, but has been posited for more than a century.Based on the clinical observation that patients with RA frequently have severe periodontal disease (gum disease), gum inflammation has long been thought to contribute to disease development in RA.However, limited understanding of the mechanisms that fuel and sustain the autoimmune attack in RA made it difficult to pinpoint a specific bacterial trigger.
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Could Gum Disease Cause Rheumatoid Arthritis?
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A type of bacteria found in severe gum disease may trigger many cases of rheumatoid arthritis, researchers reported Wednesday.The bacteria is found in about a third of people, and the researchers found evidence that 47 percent of patients with rheumatoid arthritis had evidence of an infection.Hand image shows rheumatoid arthritis, apainful auti-immune diseases that causes inflammation of the joints Val Altouninan, Science Translational MedicineIt's called Aggregatibacter actinomycetemcomitans, or "A a" for short.The bacteria damages immune system cells called neutrophils in a way that seems to enrage the immune system, which then attacks them.
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Bacteria That Causes Gum Disease Also Triggers Inflammatory Response In Rheumatoid Arthritis
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AdvertisementBacteria that are responsible for causing gum infection could trigger inflammatory responses in people with rheumatoid arthritis, reports a recent study.Researchers from Johns Hopkins Medicine have found that the bacteria Aggregatibacter actinomycetemcomitans that causes periodontal diseases could be contributing to RA, the autoimmune disease characterized by chronic inflammation of joints.Gum Disease And Rheumatoid ArthritisThe study published in Science Translational Medicine notes that A. actinomycetemcomitans stimulates the citrullinated protein production in the body, which could be leading to a series of reactions that results in RA."This is like putting together the last few pieces of a complicated jigsaw puzzle that has been worked on for many years," said Felipe Andrade, the senior author of the study, in a press release.
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