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Wednesday, February 15, 2017

Calcium imbalance within brain cells may trigger Alzheimer's disease quoting : Medical News Today

In the mitochondria of a brain cell, calcium ions control how much energy is produced for the brain to function. Until now, however, the exact mechanism that links Alzheimer's-related neurodegeneration and mitochondrial calcium imbalance was unknown. The neurodegenerative process may be caused by a calcium imbalance within the brain cell. It is possible that alterations in mitochondrial calcium exchange may be driving the disease process." A decrease in this gene's expression further suggests that the protein exchanger plays a key role in the progression of the disease.



Calcium imbalance within brain cells may trigger Alzheimer's disease
Previous studies have suggested that an imbalance of calcium in neurons might play an important role in the onset of Alzheimer's disease. Calcium in the mitochondria -- the energy factory of cells -- may be one of the keys to understanding and treating Alzheimer's disease and dementia. But if there's too much calcium -- as has been suggested to occur in Alzheimer's disease -- it can cause cells to die. Calcium ions exit a neuron's mitochondria with the help of a transporter protein called the mitochondrial sodium/calcium exchanger. "It's possible that alterations in mitochondrial calcium exchange may be driving the disease process."

Alzheimer's disease risk factors

For example, managing other health conditions — diabetes and heart conditions, such as high blood pressure, heart disease, stroke, and high cholesterol may increase a person's risk of Alzheimer's disease, according to the NIA. There's still a lot we don't know about the causes of Alzheimer's, but there are some factors associated with an increased risk of getting the disease. Alzheimer's disease affects nearly 5 million Americans, a number that's expected to balloon to 13.8 million by 2050. Here's what the science has to say about the factors that influence your risk of Alzheimer's and cognitive decline. View As: One Page SlidesAge There are some risk factors that you can't control.

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collected by :Lucy William

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