EurekAlert : declared in Worm gene could be key to developing obesity treatment

When they're well fed they have no need to roam, and when they're fully sated they enter a sleep-like state," Associate Professor Pocock said. Associate Professor Pocock and his team discovered a gene, encoding a transcription factor called ETS-5, which controls signals from the brain to the intestines. Associate Professor Pocock explained that when the intestine had stored enough fat, the brain would receive the message to stop moving, effectively putting the worm to sleep. Now that we've learned this gene family controls food intake through a feedback system to the brain, it represents a credible drug target for the treatment of obesity," he said. Monash University and Danish researchers have discovered a gene in worms that could help break the cycle of overeating and under-exercising that can lead to obesity.

Worm gene could be key to developing obesity treatment

Credit: Monash University Monash University and Danish researchers have discovered a gene in worms that could help break the cycle of overeating and under-exercising that can lead to obesity. Monash University Associate Professor Roger Pocock. When they're well fed they have no need to roam, and when they're fully sated they enter a sleep-like state," Associate Professor Pocock said. Associate Professor Pocock and his team discovered a gene, encoding a transcription factor called ETS-5, which controls signals from the brain to the intestines. Associate Professor Pocock explained that when the intestine had stored enough fat, the brain would receive the message to stop moving, effectively putting the worm to sleep.


This new animal study, carried out by Carleton University in Ottawa, Canada, looked at how exposure to BPA while pregnant could possibly increase the risk of obesity. The team of researchers fed pregnant mice BPA via their food, exposing them to doses lower than the levels deemed safe by the US Food and addiction Administration and Health Canada. In order to make a comparison, other pregnant mice were exposed to an estrogen chemical called diethylstilbestrol (DES), or not exposed to any chemicals at all. Once the mice gave birth, the researchers gave their offspring injections of the hormone leptin at various intervals. Sometimes referred to as the satiety hormone, leptin helps to inhibit the appetite by reducing feelings of hunger when the body does not need energy, reducing overeating.

about the details read more from here

collected by :Lucy William

To follow all the new news about Disease !!! All you need to know about all kinds of diseases