Drug could slow motor neuron disease quoting : medicalxpress

In the meantime, his laboratory at UQ's School of Biomedical Sciences will test the drug in a range of motor neuron disease models. Dr Woodruff ... the drug could be trialled in patients in 2019. Credit: University of Queensland A drug with the potential to delay the progression of motor neuron disease (MND) could be in human trials within three years. University of Queensland researchers have shown the anti-inflammatory drug PMX205 is effective in animals with the disease, delaying the progression of symptoms and extending survival. UQ's Dr John Lee, a Motor Neuron Disease Research Institute postdoctoral fellow who conducted the research, said PMX205 could help manage patient symptoms to improve quality and length of life. The drug has obtained "orphan drug" approval from United States and European licencing authorities, which allows for accelerated progression to human trials.




GETTY Type 2 diabetes: Insulin resistance could increase risk of Alzheimer's disease GETTY Type 2 diabetes: Insulin resistance could increase risk of Alzheimer's diseaseExperts have found the brain is especially vulnerable to the effects of insulin resistance, which triggers diabetes and is partly caused by obesity and lack of exercise. Dr James Pickett, Head of Research, at Alzheimer's Society, said: "There is strong evidence that poorly-managed diabetes can increase your risk of dementia. "We know that insulin resistance can be prevented and treated by lifestyle changes and certain insulin sensitising drugs," he said. GETTY Type 2 diabetes: The research supports findings which say exercise can reduce dementia riskSymptoms of diabetes Fri, August 19, 2016 Diabetes is a common life-long health condition.

Diabetes drug could be the first to reverse the disease

Left untreated, type 2 diabetes can lead to heart and kidney disease, nerve damage, foot ulcers and vision problems. A daily drug can reverse diabetes symptoms in mice, opening up the possibility of a much easier way for diabetics to keep their blood sugar level within safe limits. Journal reference: Nature Chemical Biology, DOI: 10.1038/nchembio.2344Read more: Let's take a knife to the world's rising tide of type 2 diabetes "This could lead to a new therapeutic strategy for treating type 2 diabetes," says Stanford, whose team believes that the drug could lead to fewer people with adult-onset diabetes becoming dependent on insulin injections. The drug was given daily, by mouth, and did not seem to have any side effects in the mice.


collected by :Lucy William

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