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Wednesday, March 1, 2017

Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics according to : WHO

Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibioticsThe World Health Organization was requested by Member States to develop a global priority pathogens list (global PPL) of antibiotic-resistant bacteria to help in prioritizing the research and development (R&D) of new and effective antibiotic treatments. Previous PPLs, issued by the Centers for Disease Control and Prevention ... To date, the selection of pathogens for R&D activities has been largely guided by small and large pharmaceutical companies according to a variety of parameters, such as perceived/unmet medical need, pressure of investors, market size, scientific discovery potential, and availability of specific technologies.



Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics
The group looked at soil bacteria compounds, known to effectively prevent other bacteria growing around them. The research partnership - involving the University of Warwick, and spanning institutions from Australia, Canada and the USA - has discovered a compound which could translate into a new drug lead for TB. A new treatment for tuberculosis (TB) is set to be developed using compounds derived from bacteria that live in soil - according an international collaboration of researchers, including the University of Warwick. It is estimated more than 250,000 TB deaths were from drug-resistant infections. In 2015 there were an estimated 10.4 million new cases of TB and 1.4 million deaths from the disease.

WHO publishes list of bacteria for which new antibiotics are urgently needed

These bacteria have become resistant to a large number of antibiotics, including carbapenems and third generation cephalosporins – the best available antibiotics for treating multi-drug resistant bacteria. WHO publishes list of bacteria for which new antibiotics are urgently needed27 February 2017 | GENEVA - WHO today published its first ever list of antibiotic-resistant "priority pathogens" – a catalogue of 12 families of bacteria that pose the greatest threat to human health. The list highlights in particular the threat of gram-negative bacteria that are resistant to multiple antibiotics. The most critical group of all includes multidrug resistant bacteria that pose a particular threat in hospitals, nursing homes, and among patients whose care requires devices such as ventilators and blood catheters. WHO's first global priority pathogen list is an important new tool to secure and guide research and development related to new antibiotics."



collected by :Lucy William

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