Medical News Today : reported that Gut bacteria affect intestines and brain in IBS patients

New research may have found a connection between gut bacteria and behavior in IBS patients, which could inform new treatments. Gut bacteria from human IBS patients transfers symptoms onto miceFor their study, the researchers used healthy, IBS-free individuals, as well as two groups of patients with IBS: one group that also had anxiety and another that did not. New research suggests that the gut's microbiota may connect intestinal and behavioral symptoms in patients with IBS. After the transplant, the mice developed gastrointestinal and behavioral symptoms similar to those of their donors. No biomarker has yet been identified for IBS, so no investigation can definitively say that somebody has IBS.

Gut bacteria impacts intestine and behaviour in IBS patients

Gut bacteria appears to alter intestinal as well as behavioural patterns in irritable bowel syndrome (IBS) patients in a discovery that points to the strength of microbiota-directed therapies. The mice proceeded to develop changes in intestinal function and behaviour similar to the donor IBS patients. The researchers said aspects of IBS that faecal transplant could provide benefit to included gastrointestinal transit and intestinal barrier dysfunction. Source: Science Translational MedicinePublished online ahead of print: DOI: 10.1126/scitranslmed.aaf6397"Transplantation of faecal microbiota from patients with irritable bowel syndrome alters gut function and behaviour in recipient mice."Authors: Giada De Palma et al. In this study that was supported by Nestle Switzerland, McMaster University researchers transferred microbiota via faecal transplants from IBS patients with or without anxiety into germ-free mice.

Gut bacteria impact intestinal and behavioural symptoms in IBS patients, study finds

Using fecal transplants, researchers transferred microbiota from IBS patients with or without anxiety into germ-free mice. Research from McMaster University has found that bacteria in the gut impacts both intestinal and behavioural symptoms in patients suffering from irritable bowel syndrome (IBS), a finding which could lead to new microbiota-directed treatments. The goal of the study was to explore whether fecal microbiota from human IBS patients with diarrhea has the ability to influence gut and brain function in recipient mice. The authors conclude that their findings raise the possibility that "microbiota-directed therapies, including pre- or probiotic treatment, may be beneficial in treating not only intestinal symptoms but also components of the behavioural manifestations of IBS." The mice went on to develop changes both in intestinal function and behavior reminiscent of the donor IBS patients, compared to mice that were transplanted with microbiota from healthy individuals.



collected by :Lucy William

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