sciencedaily : reported that Diabetes linked to bacteria invading the colon -- ScienceDaily

In humans, developing metabolic disease, particularly type 2 diabetes, is correlated with having bacteria that penetrate the mucus lining of the colon, according to a study led by Drs. The researchers are conducting follow-up studies to determine the identity of the bacteria that are invading the colon lining and are exploring remedies to prevent such bacteria encroachment. The subjects, at least 21 years old with no major health problems besides diabetes, were undergoing colonoscopy for colon cancer screening. "Alterations in bacteria have been associated with metabolic diseases, including obesity and type 2 diabetes, but mechanisms remain elusive," said Gewirtz, professor in the Institute for Biomedical Sciences at Georgia State. Metabolic syndrome is the term for a group of factors that raise a person's risk for heart disease and other health problems, such as diabetes and stroke.

Gut bacteria invading colon lining linked to type 2 diabetes

"Dr Samuel Klein, chief of the Division of Geriatrics and Nutritional Science at the Washington University School of Medicine Diabetes Research Center, said: "The data are impressive and may have opened a new field of investigation in metabolic function and type 2 diabetes . "Human samples taken from people aged at least 21 were used in this most recent study. "More research is now being carried out to find out more about the colon-invading bacteria in a bid to develop future treatments.The findings have been published in the Cellular and Molecular Gastroenterology and Hepatology journal They were recruited via the Veteran's Administration Hospital in Atlanta and had no major health problems, other than type 2 diabetes, and were being screened for colon cancer Biopsies taken from the left colon were studied, along with the individuals' medical history and gastrointestinal complaints.The researchers think the gut bacteria penetrating the epithelial cells drives inflammation which leads to insulin resistance The study stated: "We conclude that microbiota encroachment is a feature of insulin resistance-associated dysglycemia in humans. "Professor Gerwirtz said there has already been research which has looked at bacteria penetrating the epithelium, the mucus that lines the colon : "Previous studies in mice have indicated that bacteria that are able to encroach upon the epithelium might be able to promote inflammation that drives metabolic diseases, and now we've shown that this is also a feature of metabolic disease in humans, specifically type 2 diabetics who are exhibiting microbiota encroachment.

New research links diabetes to bacteria invading the colon

New American research suggests that metabolic disease, particularly type 2 diabetes, could be linked to bacteria that penetrate the mucus lining of the colon. Further research will be required to identify which bacteria are invading the colon lining. According to a European study, an increased consumption of legumes (lentils, chickpeas, beans, peas) could reduce the risk of type 2 diabetes. (Shutterstock)In this study, researchers analysed colon cell samples collected by colonoscopy from subjects aged over 21 and with no major health problems apart from diabetes. Previous studies suggest, for example, that obese people may have impaired or altered microbiota (dysbiosis) with a reduced presence of "good bacteria".


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