NEW YORK (GenomeWeb) – Researchers from two pharmaceutical companies are pursuing drugs that target the ANGPTL3 gene in a bid to treat heart disease. The companies hope to recapitulate, to some degree, the lower triglyceride and cholesterol levels seen among people with naturally occurring loss-of-function mutations in ANGPTL3. People who are homozygous for such mutations have some 70 percent lower plasma triglycerides and LDL cholesterol levels than those without.
Why Sleep Is So Important for People at Risk for Heart Disease
[5 Surprising Sleep Discoveries]"If you have several heart disease risk factors, taking care of your sleep and consulting with a clinician if you have insufficient sleep is important if you want to lower your risk of death from heart disease or stroke," lead study author Julio Fernandez-Mendoza, an assistant professor of psychiatry at Penn State College of Medicine, said in a statement. [Where Is Heart Disease Risk the Highest and Lowest? For people who are at risk for heart disease and diabetes, getting enough sleep may be especially important: Snoozing for less than 6 hours per night may increase their risk of premature death, a new study finds. At the lab, the researchers also looked at whether the participants had metabolic syndrome. The researchers looked at the relationship between metabolic syndrome, how long the participants slept at the study's start and their risk of death during the 17 years.collected by :Lucy William
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